Increased expression of pendrin in eosinophilic chronic rhinosinusitis with nasal polyps
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چکیده
منابع مشابه
Expression of cysteinyl leukotriene receptor GPR17 in eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps.
BACKGROUND The cysteinyl leukotrienes (cysLTs) are proinflammatory lipid mediators that act on the type 1 cysLT receptor (CysLT1R) in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). GPR17, a G protein-coupled orphan receptor with homology to the cysLT receptors, has been proposed as a damage sensor during inflammation. However, the expression and correlation of GPR17 and ...
متن کاملTranscriptome Analysis Reveals Distinct Gene Expression Profiles in Eosinophilic and Noneosinophilic Chronic Rhinosinusitis with Nasal Polyps
Chronic rhinosinusitis with nasal polyps (CRSwNP), one of the most prevalent chronic diseases, is characterized by persistent inflammation of sinonasal mucosa. However, the pathogenesis of CRSwNP remains unclear. Here, we performed next-generation RNA sequencing and a comprehensive bioinformatics analyses to characterize the transcriptome profiles, including mRNAs and long noncoding RNAs (lncRN...
متن کاملComparison of Expression of Cytokeratin 7 on Epithelium of Nasal Polyps and Mucosa of Chronic Rhinosinusitis
Background and Objective: Nasal polyp is the most common benign mass of the nasal cavity and it is originated from nasal cavity or sinuses. Cytokeratins (CK) are intermediate filament proteins that provide mechanical support in epithelial cells. The purpose of this study was to compare the expression of cytokeratin 7 in epithelium of nasal polyps and nasal mucosa in chronic rhinosinusitis. Mate...
متن کاملA historical cohort study of eosinophilic inflammation in chronic rhinosinusitis with nasal polyps in Okayama, Japan
Background CRSwNP(Chronic rhinosinusitis with nasal polyps) is characterized with eosinophil infiltration into sinonasal tissues in Caucasian patients. In Japan, this condition was thought to be an infectious disease (so called “empyema”) for a long time. However, after a clinical profile of ECRS(eosinophilic chronic rhinosinusitis) was first introduced by Moriyama in 2002, the prevalence of EC...
متن کاملA Global Analysis of Tandem 3′UTRs in Eosinophilic Chronic Rhinosinusitis with Nasal Polyps
BACKGROUND Alternative polyadenylation (APA) is emerging as a widespread mechanism of gene regulation. The usage of APA sites allows a single gene to encode multiple mRNA transcripts with different 3'-untranslated region (3'UTR) lengths. Many disease processes reflect the importance of the regulation of APA site switching. The objective of this study was to explore the profiling of tandem APA s...
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ژورنال
عنوان ژورنال: Brazilian Journal of Otorhinolaryngology
سال: 2019
ISSN: 1808-8694
DOI: 10.1016/j.bjorl.2018.07.005